Interphase Chromatin Dynamics in Response to Local DNA Damage
نویسندگان
چکیده
منابع مشابه
Remodelers move chromatin in response to DNA damage
DNA double-strand breaks (DSBs) are dangerous lesions that occur when both strands of the DNA double helix are broken. Repair of DSBs occurs either by homologous recombination (HR) or non-homologous end-joining (NHEJ). A fundamental distinction between the 2 pathways lies in the requirement for a homologous sequence that templates the repair: this is needed for HR but not for NHEJ. In S-phase c...
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The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, a...
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Chromatin structure and dynamics control all aspects of DNA biology yet are poorly understood, especially at large length scales. We developed an approach, displacement correlation spectroscopy based on time-resolved image correlation analysis, to map chromatin dynamics simultaneously across the whole nucleus in cultured human cells. This method revealed that chromatin movement was coherent acr...
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Cells are constantly damaged by factors that can induce DNA damage. Eukaryotic cells must rapidly load DNA repair proteins onto damaged chromatin during the DNA damage response (DDR). Chromatin-remodeling complexes use the energy from ATP hydrolysis to remodel nucleosomes and have well-established functions in transcription. Emerging lines of evidence indicate that chromatin-remodeling complexe...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.2029